A neurotoxin that blocks nAChR
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α-Bungarotoxin (trifluoroacetate salt)

Item No. 16385

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C338H529N97O105S11 • XCF3COOH
Formula Weight
7984.1
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
CC[C@H](C)[C@](C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@H](N1)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCSC)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CSSC[C@H](N5)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(NCC6=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C5=O)CC7=CC=CC=C7)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC8=CNC=N8)C(N[C@]([C@H](O)C)([H])C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CO)C(N9CCC[C@H]9C(N[C@@](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CSSC[C@H](N6)C(N[C@H](C(N[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CSSC[C@H](N%10)C(N[C@@H](CSSC[C@H](N%11)C(N[C@@H](CC(N)=O)C(N%12CCC[C@H]%12C(N[C@@H](CC%13=CNC=N%13)C(N%14CCC[C@H]%14C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N%15CCC[C@H]%15C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CO)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C%11=O)=O)=O)=O)=O)=O)C(N%16CCC[C@H]%16C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N%17CCC[C@H]%17C(N[C@@H](CC%18=CC=C(O)C=C%18)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@]([C@H](O)C)([H])C%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)C)=O)C(N%19CCC[C@H]%19C(N%20CCC[C@H]%20C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C1=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)([H])N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C338H529N97O105S11.C2HF3O2/c1-32-164(17)252(348)314(519)418-253(159(7)8)316(521)411-227-151-548-544-146-222-300(505)391-206(123-179-83-87-184(449)88-84-179)287(492)378-194(73-52-109-358-337(351)352)275(480)376-190(67-40-46-103-340)273(478)383-200(101-119-541-31)282(487)392-208(125-181-132-360-187-65-38-37-64-186(181)187)290(495)409-223-147-543-546-149-225(408-289(494)205(122-178-62-35-34-36-63-178)388-267(472)167(20)368-285(490)211(130-249(465)466)395-301(223)506)304(509)401-217(141-438)297(502)400-216(140-437)295(500)375-188(72-51-108-357-336(349)350)271(476)361-135-242(454)372-189(66-39-45-102-339)283(488)416-256(162(13)14)317(522)419-254(160(9)10)315(520)385-198(94-99-247(461)462)281(486)389-203(120-157(3)4)272(477)362-136-244(456)374-221(145-542-550-154-230(334(539)435-118-61-82-238(435)335(540)434-117-55-76-232(434)307(512)363-137-243(455)373-195(92-97-245(457)458)278(483)394-210(128-240(346)452)291(496)390-204(121-158(5)6)286(491)407-222)414-326(531)264(176(29)447)426-318(523)255(161(11)12)415-268(473)169(22)369-294(499)215(139-436)404-320(525)258(165(18)33-2)420-313(518)237-81-60-115-432(237)332(537)220(144-441)405-323(528)260(172(25)443)421-270(475)170(23)371-321(526)259(171(24)442)427-327(532)265(177(30)448)423-293(498)209(393-302(227)507)126-182-133-355-155-365-182)299(504)370-166(19)266(471)367-168(21)269(474)422-261(173(26)444)325(530)413-229-153-551-549-152-228(412-324(529)263(175(28)446)425-319(524)257(163(15)16)417-284(489)199(95-100-248(463)464)381-279(484)197(93-98-246(459)460)382-288(493)207(124-180-85-89-185(450)90-86-180)396-310(515)234-78-56-112-429(234)328(533)201(71-44-50-107-344)386-276(481)191(68-41-47-104-341)379-296(501)218(142-439)403-312(517)236-80-59-116-433(236)333(229)538)306(511)410-226-150-547-545-148-224(406-277(482)192(69-42-48-105-342)377-292(497)212(131-250(467)468)397-322(527)262(174(27)445)424-298(503)219(143-440)402-305(226)510)303(508)398-214(129-241(347)453)331(536)431-114-58-79-235(431)311(516)399-213(127-183-134-
InChi Key
KMMPUEATVXVFTF-LBDGVALOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $262

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    Product Description

    α-Bungarotoxin is a snake venom-derived toxin that irreversibly binds nicotinic acetylcholine receptors (Ki = ~2.5 µM in rat) present in skeletal muscle, blocking action of acetylcholine at the postsynaptic membrane and leading to paralysis.1,2,3 It has been widely used to characterize activity at the neuromuscular junction, which has numerous applications in neuroscience research.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Changeux, J.P., Kasai, M., and Lee, C.Y. Use of a snake venom toxin to characterize the cholinergic receptor protein. Proc. Natl. Acad. Sci. USA 67(3), 1241-1247 (1970).

    2. Mukhin, A.G., Gündisch, D., Horti, A.G., et al. 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol. Pharmacol. 57(3), 642-649 (2000).

    3. Plomp, J.J., and Molenaar, P.C. Involvement of protein kinases in the upregulation of acetylcholine release at endplates of α-bungarotoxin-treated rats. J. Physiol. 493(Pt 1), 175-186 (1996).

    4. Grady, S.R., Salminen, O., Laverty, D.C., et al. The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum. Biochem. Pharmacol. 74(8), 1235-1246 (2007).

    5. Nirthanan, S., and Gwee, M.C.E. Three-finger α-neurotoxins and the nicotinic acetylcholine receptor, forty years on. J. Pharmacol. Sci. 94(1), 1-17 (2004).