A selective PIP5K1C inhibitor
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UNC3230

Item No. 16401

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-4-thiazolecarboxamide
CAS Number
1031602-63-7
Molecular Formula
C17H20N4O2S
Formula Weight
344.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 0.2 mg/ml
λmax
287, 336 nm
SMILES
O=C(C1CCCCC1)NC2=C(C(N)=O)N=C(S2)NC3=CC=CC=C3
InChi Code
InChI=1S/C17H20N4O2S/c18-14(22)13-16(21-15(23)11-7-3-1-4-8-11)24-17(20-13)19-12-9-5-2-6-10-12/h2,5-6,9-11H,1,3-4,7-8H2,(H2,18,22)(H,19,20)(H,21,23)
InChi Key
RZCNASHHHSKTGP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $136

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    10 mg

    $216

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    Product Description

    UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).1 It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.1 At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wright, B.D., Loo, L., Street, S.E., et al. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82(4), 836-847 (2014).