Carprofen

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used in animals to combat pain and inflammation, particularly as associated with osteoarthritis.^1,2 Like many NSAIDs, carprofen inhibits both cyclooxygenases COX-1 and COX-2 (IC₅₀s = 22.3 and 3.9 µM, respectively).^3,4 It also inhibits fatty acid amide hydrolase (IC₅₀ = 74 µM), blocking the metabolism of the cannabinoid receptor ligand, arachidonoyl ethanolamide (Item No. 90050).^4,5

WARNING This product is not for human or veterinary use.

1. Malek, S., Sample, S.J., Schwartz, Z., et al. Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis. BMC Vet. Res. 8, 185 (2012).

2. Brown, D.C., Boston, R.C., Coyne, J.C., et al. Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis. J. Am. Vet. Med. Assoc. 233(8), 1278-1283 (2008).

3. Li, J., Lynch, M.P., DeMello, K.L., et al. In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyride, a potent, selective, and orally active canine COX-2 inhibitor. Bioorg. Med. Chem. 13(5), 1805-1809 (2005).

4. Favia, A.D., Habrant, D., Scarpelli, R., et al. Identification and characterization of carprofen as a multi-target FAAH/COX inhibitor. J. Med. Chem. 55(20), 8807-8826 (2012).

5. Bertolacci, L., Romeo, E., Veronesi, M., et al. A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase. J. Am. Chem. Soc. 135(1), 22-25 (2013).