A urinary biomarker
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Hexanoyl Glycine

Item No. 16412

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-1-oxohexyl-glycine
CAS Number
24003-67-6
Synonyms
  • NSC 224460
Molecular Formula
C8H15NO3
Formula Weight
173.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
OC(CNC(CCCCC)=O)=O
InChi Code
InChI=1S/C8H15NO3/c1-2-3-4-5-7(10)9-6-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)
InChi Key
UPCKIPHSXMXJOX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $49

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    50 mg

    $120

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    100 mg

    $198

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    500 mg

    $796

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    Product Description

    Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. It is normally biosynthesized from hexanoyl-CoA and glycine by the mitochondrial enzyme glycine N-acyltransferase. Increased urinary excretion of hexanoyl glycine in humans is indicative of a deficiency in medium-chain acyl-CoA dehydrogenase.1,2 Increased urinary hexanoyl glycine can also be used as a biomarker for exposure to gamma radiation.3 Levels of hexanyl glycine can also be elevated during cancer, while they are decreased 20-fold in mice following treatment with the PPARα ligand Wy 14643 (Item No. 70730).4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rinaldo, P., O'Shea, J.J., Coates, P.M., et al. Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine. N. Engl. J. Med. 319(20), 1308-1313 (1988).

    2. Tserng, K.Y., Jin, S.J., Kerr, D.S., et al. Abnormal urinary excretion of unsaturated dicarboxylic acids in patients with medium-chain acyl-CoA dehydrogenase deficiency. J. Lipid Res. 31(5), 763-761 (1990).

    3. Tyburski, J.B., Patterson, A.D., Krausz, K.W., et al. Radiation metabolomics: Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiat. Res. 170(1), 1-14 (2008).

    4. Li, F., Patterson, A.D., Krausz, K.W., et al. Metabolomics reveals that tumor xenografts induce liver dysfunction. Mol. Cell. Proteomics 12(8), 2126-2135 (2013).

    5. Zhen, Y., Krausz, K.W., Chen, C., et al. Metabolomic and genetic analysis of biomarkers for PPARα expression and activation. Mol. Endocrinol. 21(9), 2136-2151 (2007).