An agonist of PPARα
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Wy 14643

Item No. 70730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid
CAS Number
50892-23-4
Synonyms
  • NSC 310038
  • Pirinixic Acid
Molecular Formula
C14H14ClN3O2S
Formula Weight
323.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 16.5 mg/mlPBS pH 7.2: 40 µg/ml
λmax
244, 292 nm
SMILES
OC(=O)CSc1nc(cc(Cl)n1)Nc1cccc(C)c1C
InChi Code
InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
InChi Key
SZRPDCCEHVWOJX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $18

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    10 mg

    $24

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    50 mg

    $69

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    250 mg

    $212

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Wy 14643 is an agonist of peroxisome proliferator-activated receptor α (PPARα).1 It selectively transactivates PPARα over PPARγ in a reporter assay using CV-1 mouse fibroblasts when used at a concentration of 100 µM. Wy 14643 (2 mg/kg) decreases distal colon protein levels of IFN-γ, TNF-α, IL-1β, and IL-6 in a mouse model of experimental colitis induced by dextran sulfate sodium (DSS; Item No. 23250).2 Wy 14643 (0.1% w/w in the diet) reduces hepatic triglycerides, leukocyte recruitment, and fibrosis in a mouse model of methionine- and choline-deficient diet-induced steatohepatitis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. The Journal of Biological Chemisty 272(6), 3406-3410 (1997).

    2. Azuma, Y.-T., Nishiyama, K., Matsuo, Y., et al. PPARα contributes to colonic protection in mice with DSS-induced colitis. Int. Immunopharmacol. 10(10), 1261-1267 (2010).

    3. Ip, E., Farrell, G., Hall, P., et al. Administration of the potent PPARα agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 39(5), (2004).

    Product Citations

    Das, S., Finney, A.C., Anand, S.K., et al. Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis. Nat. Metab. 6(10), 1939-1962 (2024).

    Kamarajugadda, S., Becker, J.R., Hanse, E.A., et al. Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation. Oncotarget 7(30), 47674-47686 (2016).

    Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation. Front. Bioeng. Biotechnol. 4(27), (2016).

    Hsu, W.-H., Chen, T.-H., Lee, B.-H., et al. Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem. Toxicol. 64, 94-103 (2014).

    Hsu, W.-H., Liao, T.-H., Lee, B.-H., et al. Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation. J. Funct. Foods 5(1), (2012).