An immunomodulatory antiviral complex
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Isoprinosine

Item No. 16492

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(dimethylamino)-2-propanol 4-(acetylamino)benzoate inosine
CAS Number
36703-88-5
Synonyms
  • Inosine pranobex
  • NP 113
  • NPT 10381
Molecular Formula
C10H12N4O5 • 3C9H9NO3 • 3C5H13NO
Formula Weight
1115.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 14 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
259 nm
SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC=NC3=O)O1.OC(C4=CC=C(NC(C)=O)C=C4)=O.CC(O)CN(C)C.OC(C5=CC=C(NC(C)=O)C=C5)=O.CC(O)CN(C)C.OC(C6=CC=C(NC(C)=O)C=C6)=O.CC(O)CN(C)C
InChi Code
InChI=1S/C10H12N4O5.3C9H9NO3.3C5H13NO/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18;3*1-6(11)10-8-4-2-7(3-5-8)9(12)13;3*1-5(7)4-6(2)3/h2-4,6-7,10,15-17H,1H2,(H,11,12,18);3*2-5H,1H3,(H,10,11)(H,12,13);3*5,7H,4H2,1-3H3/t4-,6-,7-,10-;;;;;;/m1.
InChi Key
YLDCUKJMEKGGFI-QCSRICIXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Product Description

    Isoprinosine is a complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio. It has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production.1,2,3 Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute sclerosing panencephalitis.3,4 It also restores depressed immune responses in cancer patients after irradiation and reduces the incidence of infection in leukemia patients undergoing chemotherapy.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fischbach, M., and Talal, N. Ability of isoprinosine to restore interleukin-2 production and T cell proliferation in autoimmune mice. Clin. Exp. Immunol. 61, 242-247 (1985).

    2. Tsang, K.Y., Fudenberg, H.H., Galbraith, G.M.P., et al. Partial restoration of impaired interleukin-2 production and tac antigen (putative interleukin-2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro. J. Clin. Invest. 75, 1538-1544 (2015).

    3. Caspritz, G., and Hadden, J. The immunopharmacology of immunotoxicology, and immunorestoration. Toxicol. Pathol. 15(3), 320-332 (1987).

    4. Garg, R.K. Subacute sclerosing panencephalitis. Postgrad. Med. J. 78, 63-70 (2015).