A fluorogenic substrate of α-galactosidase
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4-Methylumbelliferyl-α-D-Galactopyranoside

Item No. 16551

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(α-D-galactopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one
CAS Number
38597-12-5
Synonyms
  • 4-Methylumbelliferyl α-D-galactoside
  • MU-α-Gal
  • 4-MU-α-Gal
Molecular Formula
C16H18O8
Formula Weight
338.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 1 mg/ml
λmax
213, 316 nm
SMILES
OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](OC2=CC=C(C(C)=CC(O3)=O)C3=C2)O1
InChi Code
InChI=1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13+,14+,15-,16+/m1/s1
InChi Key
YUDPTGPSBJVHCN-CHUNWDLHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $43

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    25 mg

    $97

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    50 mg

    $129

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    100 mg

    $172

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    Product Description

    4-Methylumbelliferyl-α-D-galactopyranoside (4-MU-α-Gal) is a fluorogenic substrate of α-galactosidase.1,2 In addition to its use in characterizing novel α-galactosidases, 4-MU-α-Gal is used in assays to evaluate deficiency in α-galactosidase activity related to Fabry disease.3 Hydrolysis of 4-MU-α-Gal releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mayes, J.S., Scheerer, J.B., Sifers, R.N., et al. Differential assay for lysosomal alpha-galactosidases in human tissues and its application to Fabry’s disease. Clin. Chim. Acta 112(2), 248-251 (1981).

    2. Oh, J.-K., Lee, J.-Y., Park, H.-K., et al. α-Galactosidase activity in human saliva. Arch. Oral Biol. 53(9), 842-848 (2008).

    3. Sista, R.S., Wang, T., Wu, N., et al. Multiplex newborn screening for Pompe, Fabry, Hunter, Gaucher, and Hurler diseases using a digital microfluidic platform. Clin. Chim. Acta. 424, 12-18 (2013).

    4. Zhi, H., Wang, J., Wang, S., et al. Fluorescent properties of hymecromone and fluorimetric analysis of hymecromone in compound dantong capsule. J. Spectrosc. 147128 (2013).