Ferutinin

Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) α (IC₅₀ = 33.1 nM) and an agonist/antagonist for ERβ (IC₅₀ = 180.5 nM).¹ It also demonstrates ionophoretic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at a concentration range of 1-50 µM.^2,3,4 Ferutinin is cytotoxic to MCF-7 breast and TCC bladder cancer cells as well as human foreskin HFF3 fibroblasts (IC₅₀s = 29, 24, and 36 µg/ml in vitro after 72 hours of exposure).³

WARNING This product is not for human or veterinary use.

1. Ikeda, K., Arao, Y., Otsuka, H., et al. Terpenoids found in the Umbelliferae family act as agonists/antagonists for ERα and ERβ: Differential transcription activity between ferutinine-liganded ERα and ERβ. Biochem. Biophys. Res. Commun. 291(2), 354-360 (2002).

2. Abramov, A.Y., Zamaraeva, M.V., Hagelgans, A.I., et al. Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers. Biochim. Biophys. Acta 1512(1), 98-110 (2001).

3. Matin, M.M., Nakhaeizadeh, H., Bahrami, A.R., et al. Ferutinin, an apoptosis inducing terpenoid from Ferula ovina. Asian Pac. J. Cancer Prev. 15(5), 2123-2128 (2014).

4. Zamaraeva, M.V., Charishnikova, O., Saidkhodjaev, A., et al. Calcium mobilization by the plant estrogen ferutinin does not induce blood platelet aggregation. Pharmacol. Rep. 62(6), 1117-1126 (2010).