A potent inhibitor of JAK3
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ZM 39923 (hydrochloride)

Item No. 16729

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone, monohydrochloride
CAS Number
1021868-92-7
Synonyms
  • JAK3 Inhibitor IV
  • Janus-Associated Kinase 3 Inhibitor IV
Molecular Formula
C23H25NO • HCl
Formula Weight
367.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:2): 0.25 mg/mlDMSO: 5 mg/mlEthanol: 2 mg/ml
λmax
249, 285, 336, 346 nm
SMILES
O=C(CCN(CC1=CC=CC=C1)C(C)C)C2=CC3=CC=CC=C3C=C2.Cl
InChi Code
InChI=1S/C23H25NO.ClH/c1-18(2)24(17-19-8-4-3-5-9-19)15-14-23(25)22-13-12-20-10-6-7-11-21(20)16-22;/h3-13,16,18H,14-15,17H2,1-2H3;1H
InChi Key
NJTUORMLOPXPBY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 µM, respectively).1 In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the transglutaminase Factor XIIIa (IC50s= 10 and 25 nM, respectively).2 It breaks down in neutral buffer to form ZM 449829, which is also an inhibitor of JAK3, TGM2, and Factor XIIIa.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brown, G.R., Bamford, A.M., Bowyer, J., et al. Naphthyl ketones: A new class of Janus kinase 3 inhibitors. Bioorg. Med. Chem. Lett. 10(6), 575-579 (2000).

    2. Lai, T.-S., Liu, Y., Tucker, T., et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem. Biol. 15(9), 969-978 (2008).