A potent, selective FP receptor antagonist
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AL 8810

Item No. 16735

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,15R-dihydroxy-11β-fluoro-15-(2,3-dihydro-1H-inden-2-yl)-16,17,18,19,20-pentanor-prosta-5Z,13E-dien-1-oic acid
CAS Number
246246-19-5
Molecular Formula
C24H31O4F
Formula Weight
402.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: misciblePBS (pH 7.2): .05 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@H](O)C2CC3=CC=CC=C3C2)[C@@H](F)C1
InChi Code
InChI=1S/C24H31FO4/c25-21-15-23(27)20(9-3-1-2-4-10-24(28)29)19(21)11-12-22(26)18-13-16-7-5-6-8-17(16)14-18/h1,3,5-8,11-12,18-23,26-27H,2,4,9-10,13-15H2,(H,28,29)/b3-1-,12-11+/t19-,20-,21+,22+,23+/m1/s1
InChi Key
WTYSXBKKVNOOIX-JTGCGUAKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $119

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    5 mg

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    10 mg

    $891

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    25 mg

    $1,782

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    Product Description

    AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this concentration, with EC50 values of approximately 430 nM. AL 8810 fully antagonized the bimatoprost-induced calcium mobilization in Swiss 3T3 fibroblasts at 100 µM, indicating that bimatoprost acts as an FP agonist in this preparation.2 The Ki for the inhibition of several potent agonists at the cloned human ciliary body FP receptor is in the range of 1-2 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F2α analog with selective antagonist effects at the prostaglandin F2α (FP) receptor. J. Pharmacol. Exp. Ther. 290(3), 1278-1284 (1999).

    2. Sharif, N.A., Williams, G.W., and Kelly, C.R. Bimatoprost and its free acid are prostaglandin FP receptor agonists. Eur. J. Pharmacol. 432(2-3), 211-213 (2001).

    3. Sharif, N.A., Kelly, C.R., and Crider, J.Y. Agonist activity of Bimatoprost, Travoprost, Latanoprost, Unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor. J. Ocul. Pharmacol. Ther. 18, 313-324 (2002).

    Product Citations

    Ahmad, S.F., Akoum, A., and Horne, A.W. Selective modulation of the prostaglandin F2a pathway markedly impacts on endometriosis progression in a xenograft mouse model. Mol. Hum. Reprod. 21(12), 905-916 (2015).

    Roh, Y.J., Park, Y.G., Kang, S., et al. Effects of AFP-172 on COX-2-induced angiogenic activities on human umbilical vein endothelial cells. Graefes Arch. Clin. Exp. Ophthalmol. 250(12), 1765-1775 (2012).