A potent FoxO1 inhibitor
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AS-1842856

Item No. 16761

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS Number
836620-48-5
Synonyms
  • FOXO1 Inhibitor
Molecular Formula
C18H22FN3O3
Formula Weight
347.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.5 mg/ml
λmax
211, 234, 291 nm
SMILES
O=C1C(C(O)=O)=CN(CC)C2=C1C(N)=C(F)C(NC3CCCCC3)=C2
InChi Code
InChI=1S/C18H22FN3O3/c1-2-22-9-11(18(24)25)17(23)14-13(22)8-12(15(19)16(14)20)21-10-6-4-3-5-7-10/h8-10,21H,2-7,20H2,1H3,(H,24,25)
InChi Key
MOMCHYGXXYBDCD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $35

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    5 mg

    $85

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    10 mg

    $119

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    AS-1842856 is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1; IC50 = 33 nM in HepG2 cells).1 Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). AS-1842856 also inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nagashima, T., Shigematsu, N., Maruki, R., et al. Discovery of novel forkhead box O1 inhibitors for treating Type 2 Diabetes: Improvement of fasting glycemia in diabetic db/db mice. Mol. Pharmacol. 78(5), 961-970 (2010).

    2. Liu, L., Zheng, L.D., Zou, P., et al. FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes. Cell Cycle 15(15), 2033-2041 (2016).

    3. Zou, P., Liu, L., Zheng, L., et al. Targeting FoxO1 with AS1842856 suppresses adipogenesis. Cell Cycle 13(23), 3759-3767 (2014).