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Item № 16791
CAS № 251565-85-2
Purity ≥98%
product image
                (CAS 251565-85-2)
     1 mg $29.00 0.00
     5 mg $94.00 0.00
     10 mg $160.00 0.00
     50 mg $725.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

  • AZ 242
  • GalidaTM

Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARα demonstrates a particular role in fatty acid oxidation whereas PPARγ is known to be involved in adipocyte differentiation and lipid storage. Tesaglitazar, a dihydro cinnamate derivative, is a dual agonist of PPARα and γ that demonstrates IC50 values of 1 and 0.2 µM, respectively in ligand binding assays.1 At 3 µM/kg/day for three weeks, tesaglitazar has been used to reduce insulin resistance in obese Zucker rats.2 Furthermore, it has been investigated clinically for its potential to address disorders in glucose and lipid metabolism in patients with type 2 diabetes.3

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Technical Information
Formal Name
(αS)-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-benzenepropanoic acid
CAS Number
  • AZ 242
  • GalidaTM
Molecular Formula
Formula Weight
A crystalline solid
225, 275 nm
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Room temperature in continental US; may vary elsewhere
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Cronet, P., Petersen, J.F.W., Folmer, R., et al. Structure of the PPARα and -γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family Structure 9(8), 699-706 (2001).

2. Wallenius, K., Kjellstedt, A., Thalén, P., et al. The PPARα/γ agonist, tesaglitazar, improves insulin mediated switching of tissue glucose and free fatty acid utilization in vivo in the obese zucker rat PPAR Research 2013, 1-14 (2013).

3. Wilding, J.P.H., Gause-Nilsson, I., Persson, A., et al. Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes Diab.Vasc.Dis.Res. 4(3), 194-203 (2007).

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