We collect cookies for vital website function and to better serve our customers. By continuing to browse you agree to the storing of cookies on your device. See our privacy policy for details.

Tesaglitazar

Item № 16791
CAS № 251565-85-2
Purity ≥98%
product image
                (CAS 251565-85-2)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $29.00 0.00
     5 mg $94.00 0.00
     10 mg $160.00 0.00
     50 mg $725.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • AZ 242
  • GalidaTM

Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARα demonstrates a particular role in fatty acid oxidation whereas PPARγ is known to be involved in adipocyte differentiation and lipid storage. Tesaglitazar, a dihydro cinnamate derivative, is a dual agonist of PPARα and γ that demonstrates IC50 values of 1 and 0.2 µM, respectively in ligand binding assays.1 At 3 µM/kg/day for three weeks, tesaglitazar has been used to reduce insulin resistance in obese Zucker rats.2 Furthermore, it has been investigated clinically for its potential to address disorders in glucose and lipid metabolism in patients with type 2 diabetes.3

Recommended Products

Related Products
View Related Product Categories
Technical Information
Formal Name
(αS)-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-benzenepropanoic acid
CAS Number
251565-85-2
Synonyms
  • AZ 242
  • GalidaTM
Molecular Formula
C20H24O7S
Formula Weight
408.5
Purity
≥98%
Formulation
A crystalline solid
λmax
225, 275 nm
SMILES
OC([C@@H](OCC)CC1=CC=C(OCCC2=CC=C(OS(C)(=O)=O)C=C2)C=C1)=O
InChI Code
InChI=1S/C20H24O7S/c1-3-25-19(20(21)22)14-16-6-8-17(9-7-16)26-13-12-15-4-10-18(11-5-15)27-28(2,23)24/h4-11,19H,3,12-14H2,1-2H3,(H,21,22)/t19-/m0/s1
InChI Key
CXGTZJYQWSUFET-IBGZPJMESA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Cronet, P., Petersen, J.F.W., Folmer, R., et al. Structure of the PPARα and -γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family Structure 9(8), 699-706 (2001).

2. Wallenius, K., Kjellstedt, A., Thalén, P., et al. The PPARα/γ agonist, tesaglitazar, improves insulin mediated switching of tissue glucose and free fatty acid utilization in vivo in the obese zucker rat PPAR Research 2013, 1-14 (2013).

3. Wilding, J.P.H., Gause-Nilsson, I., Persson, A., et al. Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetes Diab.Vasc.Dis.Res. 4(3), 194-203 (2007).

Technical Support
Contact Us
  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Cayman Contract Services

We work with scientists to accelerate their research, drug discovery, and drug development needs through our expertise in the following areas:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

Toll Free: (800) 364-9897

(USA and Canada Only)

Fax: (734) 971-3640