A potent, bioavailable inhibitor of PI3Kγ and PI3Kδ
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IPI-145

Item No. 16800

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone
CAS Number
1201438-56-3
Synonyms
  • Duvelisib
  • INK1197
Molecular Formula
C22H17ClN6O
Formula Weight
416.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 10 mg/ml
λmax
213, 239, 270, 344 nm
SMILES
C[C@@H](C1=CC(C=CC=C2Cl)=C2C(N1C3=CC=CC=C3)=O)NC4=C5C(N=CN5)=NC=N4
InChi Code
InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1
InChi Key
SJVQHLPISAIATJ-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $88

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    10 mg

    $124

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    25 mg

    $264

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    Product Description

    IPI-145 is a potent inhibitor of the phosphoinositide 3-kinase (PI3K) isoforms PI3Kγ and PI3Kδ (IC50s = 0.24 and 50 nM, respectively).1 It is orally bioavailable and selective.1 As PI3Kγ and PI3Kδ are preferentially expressed in immune cells, IPI-145 has profound effects in collagen-induced and adjuvant-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus animal models.1,2 It also has potential applications in immunotherapy and in certain cancers.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Winkler, D.G., Faia, K.L., DiNitto, J.P., et al. PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem. Biol. 20(11), 1364-1374 (2013).

    2. Boyle, D.L., Kim, H.R., Topolewski, K., et al. Novel phosphoinositide 3-kinase δ,γ inhibitor: Potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. J. Pharmacol. Exp. Ther. 348(2), 271-280 (2014).

    3. Mockler, M.B., Conroy, M.J., and Lysaght, J. Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. Front. Oncol. 4(107), 1-11 (2014).

    4. Falasca, M., and Maffucci, T. Targeting p100γ in gastrointestinal cancers: Attack on multiple fronts. Front. Physiol. 5(391), 1-10 (2014).