Latanoprost (CAS 130209-82-4) | Cayman Chemical
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Latanoprost

Item № 16812
CAS № 130209-82-4
Purity ≥98%
product image
                (CAS 130209-82-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $45.00 0.00
     5 mg $135.00 0.00
     10 mg $180.00 0.00
     50 mg $788.00 0.00

Pricing updated 2018-11-14. Prices are subject to change without notice.

Description
Synonyms
  • CAY530500
  • 17-phenyl-13,14-dihydro trinor PGF isopropyl ester
  • 17-phenyl-13,14-dihydro trinor Prostaglandin F isopropyl ester

Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F (17-phenyl-13,14-dihydro PGF). It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects.1,2,3 The EC50 value of latanoprost (tested as the free acid) for FP receptors is 3.6 nM.4

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Technical Information
Formal Name
9α,11α,15R-trihydroxy-17-phenyl-18,19,20-trinor-prost-5Z-en-1-oic acid, isopropyl ester
CAS Number
130209-82-4
Synonyms
  • CAY530500
  • 17-phenyl-13,14-dihydro trinor PGF isopropyl ester
  • 17-phenyl-13,14-dihydro trinor Prostaglandin F isopropyl ester
Molecular Formula
C26H40O5
Formula Weight
432.6
Purity
≥98%
Formulation
A solution in methyl acetate
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1
InChI Code
InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
InChI Key
GGXICVAJURFBLW-CEYXHVGTSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Lindén, C., Nuija, E., and Alm, A. Effects on IOP restoration and blood-aqueous barrier after long term treatment with latanoprost in open angle glaucoma and ocular hypertension British Journal of Ophthalmology 81, 370-372 (1997).

2. Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients Ophthalmology 103, 1916-1924 (1996).

3. Alm, A., Villumsen, J., Törnquist, P., et al. Intraocular pressure-reducing effect of PhXA41 in patients with increased eye pressure. A one-month study Ophthalmology 100, 1312-1317 (1993).

4. Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment Drugs of the Future 17, 691-704 (1992).

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