A potent inhibitor of virulence gene expression
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LED209

Item No. 16844

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-phenyl-4-[[(phenylamino)thioxomethyl]amino]-benzenesulfonamide
CAS Number
245342-14-7
Molecular Formula
C19H17N3O2S2
Formula Weight
383.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 0.15 mg/ml
λmax
295 nm
SMILES
S=C(Nc1ccc(cc1)S(=O)(=O)Nc1ccccc1)Nc1ccccc1
InChi Code
InChI=1S/C19H17N3O2S2/c23-26(24,22-17-9-5-2-6-10-17)18-13-11-16(12-14-18)21-19(25)20-15-7-3-1-4-8-15/h1-14,22H,(H2,20,21,25)
InChi Key
HNDRSTUKPCLQLT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Bacterial pathogens require the conserved membrane histidine sensor kinase (QseC) to detect both host-derived adrenergic signals and the bacterial autoinducer-3 (AI-3), thus activating a signaling cascade that induces virulence gene expression.1 LED209 is a potent QseC inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression at 5 pM in vitro.2 While LED209 inhibits virulence of enterohemorrhagic E. coli, S. typhimurium, and F. tularensis, it does not inhibit pathogen growth, a highly desirable feature of antimicrobial agents to prevent drug resistance.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sperandio, V., Torres, A.G., Jarvis, B., et al. Bacteria-host communication: The language of hormones. Proc. Natl. Acad. Sci. USA 100(15), 8951-8956 (2003).

    2. Rasko, D.A., Moreira, C.G., Li, D.R., et al. Targeting QseC signaling and virulence for antibiotic development. Science 321, 1078-1080 (2008).