R-7050

R-7050 is a cell-permeable antagonist of signaling through the TNF-α receptor complex (EC₅₀ = 0.631 µM).¹ It blocks TNF-α-induced binding of TNF-α receptor I with TNF-α receptor-associated death domain protein and receptor interacting protein 1, which, in turn, prevents internalization of the receptor complex.¹ R-7050 is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.¹ It has been used to investigate the role of TNF-α in neurovascular injury and mycotoxin-induced anorexia.^2,3

WARNING This product is not for human or veterinary use.

1. Gururaja, T.L., Yung, S., Ding, R., et al. A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem. Biol. 14(10), 1105-1118 (2007).

2. King, M.D., Alleyne, C.H., Jr., and Dhandapani, K.M. TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci. Lett. 542, 92-96 (2013).

3. Wu, W., and Zhang, H. Role of tumor necrosis factor-α and interleukin-1β in anorexia induction following oral exposure to the trichothecene deoxynivalenol (vomitoxin) in the mouse. J. Toxicol. Sci. 39(6), 875-886 (2014).