An antagonist of TNF-α receptor signaling
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R-7050

Item No. 16870

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
CAS Number
303997-35-5
Synonyms
  • TNF-α Antagonist III
Molecular Formula
C16H8ClF3N4S
Formula Weight
380.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 1 mg/ml
λmax
220, 310, 325, 340 nm
SMILES
ClC1=CC(N2C3=NN=C2C(F)(F)F)=C(C=C1)N=C3SC4=CC=CC=C4
InChi Code
InChI=1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H
InChi Key
SUUMKHOVGVYGOP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $169

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    25 mg

    $336

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    Product Description

    R-7050 is a cell-permeable antagonist of signaling through the TNF-α receptor complex (EC50 = 0.631 µM).1 It blocks TNF-α-induced binding of TNF-α receptor I with TNF-α receptor-associated death domain protein and receptor interacting protein 1, which, in turn, prevents internalization of the receptor complex.1 R-7050 is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.1 It has been used to investigate the role of TNF-α in neurovascular injury and mycotoxin-induced anorexia.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gururaja, T.L., Yung, S., Ding, R., et al. A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem. Biol. 14(10), 1105-1118 (2007).

    2. King, M.D., Alleyne, C.H., Jr., and Dhandapani, K.M. TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci. Lett. 542, 92-96 (2013).

    3. Wu, W., and Zhang, H. Role of tumor necrosis factor-α and interleukin-1β in anorexia induction following oral exposure to the trichothecene deoxynivalenol (vomitoxin) in the mouse. J. Toxicol. Sci. 39(6), 875-886 (2014).