A potent inhibitor of MELK
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OTSSP167 (hydrochloride)

Item No. 16873

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethan-1-one, monohydrochloride
CAS Number
1431698-10-0
Molecular Formula
C25H28Cl2N4O2 • HCl
Formula Weight
523.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:9): 0.1 mg/mlEthanol: 1 mg/ml
λmax
220, 305 nm
SMILES
CC(C1=CN=C(C=CC(C2=CC(Cl)=C(O)C(Cl)=C2)=N3)C3=C1N[C@H]4CC[C@H](CN(C)C)CC4)=O.Cl
InChi Code
InChI=1S/C25H28Cl2N4O2.ClH/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3;/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29);1H/t15-,17-;
InChi Key
XDGWHISAOWEFML-BFLZMHAMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    Product Description

    OTSSP167 is a potent inhibitor of MELK (IC50 = 0.41 nM).1 It suppresses the growth of diverse cancer cell lines at low nanomolar concentrations.1 It also blocks the phosphorylation of MELK-specific substrates and reduces the ability of MCF-7 breast cancer cells to invade and form spheroids in Matrigel.1 OTSSP167 is also effective in vivo when delivered either orally or intravenously, suppressing the growth of xenograft tumors in mice.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chung, S., Suzuki, H., Miyamoto, T., et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget 3(12), 1629-1640 (2012).

    2. Chung, S., and Nakamura, Y. MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells. Cell Cycle 12(11), 1655-1656 (2013).