A natural alkaloid with therapeutic actions
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(+)-Evodiamine

Item No. 16885

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,13,13bS,14-tetrahydro-14-methyl-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
CAS Number
518-17-2
Synonyms
  • D-Evodiamine
Molecular Formula
C19H17N3O
Formula Weight
303.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 1 mg/ml
λmax
224, 270 nm
SMILES
O=C1C2=CC=CC=C2N(C)[C@@]3([H])N1CCC4=C3NC5=C4C=CC=C5
InChi Code
InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3/t18-/m0/s1
InChi Key
TXDUTHBFYKGSAH-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $41

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    100 mg

    $72

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    250 mg

    $134

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    1 g

    $467

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Evodiamine is a natural indole alkaloid found in the fruits of Wu Zhu Yu, a plant used in traditional Chinese medicine. Studies involving evodiamine have demonstrated beneficial effects in cancer, obesity, inflammation, and many other conditions.1,2,3 It can act as an aryl hydrocarbon antagonist (Ki = 28 nM), activator of the transient receptor potential vanilloid 1 channel (EC50 = 45 nM), and inhibit signaling through NF-κB.1,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, H., Gong, W., Wang, Z., et al. Pharmacological actions of multi-target-directed evodiamine. Molecules 18(2), 1826-1843 (2013).

    2. Wang, T., Wang, X., and Yamashita, H. Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway. FEBS Lett. 583(22), 3655-3659 (2009).

    3. Ogasawara, M., Matsubara, T., and Suzuki, H. Screening of natural compounds for inhibitory activity on colon cancer cell migration. Biol. Pharm. Bull. 24(6), 720-723 (2001).

    4. Pearce, L.V., Petukhov, P.A., Szabo, T., et al. Evodiamine functions as an agonist for the vanilloid receptor TRPV1. Org. Biomol. Chem. 2, 2281-2286 (2004).

    5. Takada, Y., Kobayashi, Y., and Aggarwal, B.B. Evodiamine abolishes constitutive and inducible NF-κB activation by inhibiting IκBα kinase activation, thereby suppressing NF-κB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. The Journal of Biological Chemisty 280(17), 17203-17212 (2005).