A deubiquitylase and deSUMOylase inhibitor
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NSC 632839

Item No. 16893

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-bis[(4-methylphenyl)methylene]-4-piperidinone, monohydrochloride
CAS Number
157654-67-6
Synonyms
  • F6
  • Ubiquitin Isopeptidase Inhibitor II
Molecular Formula
C21H21NO • HCl
Formula Weight
339.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 0.25 mg/ml
λmax
240, 345 nm
SMILES
CC1=CC=C(/C=C2C(/C(CNC\2)=C\C3=CC=C(C)C=C3)=O)C=C1.Cl
InChi Code
InChI=1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11-,20-12-;
InChi Key
ZOKZLTXPTLIWOJ-GRVJEYRUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 µM, respectively.1 It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 µM in cells sensitized by E1A, an adenoviral oncogene).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nicholson, B., Leach, C.A., Goldenberg, S.J., et al. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci. 17(6), 1035-1043 (2008).

    2. Aleo, E., Henderson, C.J., Fontanini, A., et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66(18), 9235-9244 (2006).