A potent, reversible inhibitor of p38α MAPK
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JX-401

Item No. 16898

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-methanone
CAS Number
349087-34-9
Synonyms
  • p38 MAPK Inhibitor VI
  • p38 Mitogen-activated Protein Kinase Inhibitor VI
Molecular Formula
C21H25NO2S
Formula Weight
355.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:5): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
210, 265 nm
SMILES
O=C(C1=CC=C(SC)C=C1OC)N(CC2)CCC2CC3=CC=CC=C3
InChi Code
InChI=1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3
InChi Key
OMGLGPKQUFSRNN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $123

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    10 mg

    $213

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    50 mg

    $902

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    Product Description

    JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).1 It does not inhibit the p38γ isoform.1 JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Friedmann, Y., Shriki, A., Bennett, E.R., et al. JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol. Pharmacol. 70(4), 1395-1405 (2006).