A potent inhibitor of TrkA
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GW 441756

Item No. 16915

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one
CAS Number
504433-23-2
Molecular Formula
C17H13N3O
Formula Weight
275.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/ml
λmax
285, 375, 470, 500 nm
SMILES
CN1C=C(/C=C2C(NC3=C/2N=CC=C3)=O)C4=CC=CC=C41
InChi Code
InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9+
InChi Key
NXNQLECPAXXYTR-UKTHLTGXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $70

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    10 mg

    $125

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    Product Description

    GW 441756 is a potent inhibitor of TrkA (IC50 = 2 nM).1 It displays >100-fold selectivity over a panel of related kinases.1 GW 441756 has been used to clarify the role of TrkA in regulating gene expression in neuroblastoma cells and, more recently, in amyloid-β protein precursor cleavage in neuroglioma cells.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wood, E.R., Kuyper, L., Petrov, K.G., et al. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: Oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14(4), 953-957 (2004).

    2. Jung, E.J., Lee, S.Y., and Kim, C.W. Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cells. Proteomics 13(2), 355-367 (2013).

    3. Zhang, Q., Descamps, O., Hart, M.J., et al. Paradoxical effect of TrkA inhibition in Alzheimer’s disease models. J. Alzheimers Dis. 40(3), 605-617 (2014).