A selective HDAC3 inhibitor
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RGFP966

Item No. 16917

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
CAS Number
1357389-11-7
Molecular Formula
C21H19FN4O
Formula Weight
362.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
245, 285 nm
SMILES
FC1=CC(N)=C(NC(/C=C/C2=CN(C/C=C/C3=CC=CC=C3)N=C2)=O)C=C1
InChi Code
InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
InChi Key
BLVQHYHDYFTPDV-VCABWLAWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $35

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    5 mg

    $85

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    10 mg

    $152

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    Product Description

    RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM.1 At 10 mg/kg, RGFP966 can facilitate the extinction of cocaine-seeking behavior and enhance long-term object memory acquisition/consolidation in mice.1 At 10 µM, RGFP966 can also induce apoptosis of cutaneous T cell lymphoma cells by disrupting their DNA replication activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Malvaez, M., McQuown, S.C., Rogge, G.A., et al. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc. Natl. Acad. Sci. USA 110(7), 2647-2652 (2013).

    2. Wells, C.E., Bhaskara, S., Stengel, K.R., et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One 8(7), 1-13 (2013).