A selective HDAC3 inhibitor
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BG45

Item No. 16918

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-aminophenyl)-2-pyrazinecarboxamide
CAS Number
926259-99-6
Molecular Formula
C11H10N4O
Formula Weight
214.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
267 nm
SMILES
NC1=C(NC(C2=NC=CN=C2)=O)C=CC=C1
InChi Code
InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16)
InChi Key
LMWPVSNHKACEKW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $90

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    10 mg

    $168

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    25 mg

    $392

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    50 mg

    $696

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    Cayman Chemical
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    Product Description

    BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively).1 At concentrations up to 50 mg/kg, BG45 alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Minami, J., Suzuki, R., Mazitschek, R., et al. Histone deacetylase 3 (HDAC3) as a novel therapeutic target in multiple myeloma. Leukemia 28(3), 680-689 (2014).