A dual inhibitor of HDAC6 and HDAC8
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BRD73954

Item No. 16919

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
CAS Number
1440209-96-0
Molecular Formula
C16H16N2O3
Formula Weight
284.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
SMILES
O=C(C1=CC=CC(C(NO)=O)=C1)NCCC2=CC=CC=C2
InChi Code
InChI=1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20)
InChi Key
FIHKWEQJEDRIFS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $90

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    5 mg

    $392

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    10 mg

    $696

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    Product Description

    BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively).1 It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 µM, respectively). BRD73954 (10 µM) increases acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Olson, D.E., Wagner, F.F., Kaya, T., et al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J. Med. Chem. 56(11), 4816-4820 (2013).