A modified nucleoside and biomarker
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Labeled Version(s)
440211-Methyladenosine-d3 (hydriodide)
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1-Methyladenosine

Item No. 16937

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-adenosine
CAS Number
15763-06-1
Synonyms
  • m1A
  • 1-methyl Ado
  • NSC 92165
Molecular Formula
C11H15N5O4
Formula Weight
281.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
259 nm
SMILES
N=C(N(C)C=N1)C2=C1N(C=N2)[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3
InChi Code
InChI=1S/C11H15N5O4/c1-15-3-14-10-6(9(15)12)13-4-16(10)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11-12,17-19H,2H2,1H3/t5-,7-,8-,11-/m1/s1
InChi Key
GFYLSDSUCHVORB-IOSLPCCCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    1-Methyladenosine is a modified nucleoside generated by the processing of tRNA by methyltransferases.1,2,3 Urine and serum levels of 1-methyladenosine are elevated in several forms of cancer.4,5,6,7 Urine levels of 1-methyladenosine also increase during active rheumatoid arthritis.8

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Munns, T.W., and Sims, H.F. Methylation and processing of transfer ribonucleic acid in mammalian and bacterial cells. The Journal of Biological Chemisty 250(6), 2143-2149 (1975).

    2. Vold, B. Modified nucleosides of Bacillus subtilis transfer ribonucleic acids. J. Bacteriol. 127(1), 258-267 (1976).

    3. Chujo, T., and Suzuki, T. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. RNA 18(12), 2269-2276 (2012).

    4. Reynaud, C., Bruno, C., Boullanger, P., et al. Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies. Cancer Lett. 255-262 (1991).

    5. Seidel, A., Brunner, S., Seidel, P., et al. Modified nucleosides: An accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control. Br. J. Cancer. 94(11), 1726-1733 (2006).

    6. Hsu, W.Y., Chen, C.J., Huang, Y.C., et al. Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. PLoS One 8(12), 1-8 (2013).

    7. Chen, F., Xue, J., Zhou, L., et al. Identification of serum biomarkers of hepatocarcinoma through liquid chromatography/mass spectrometry-based metabonomic method. Anal. Bioanal. Chem. 401(6), 1899-1904 (2011).

    8. Tebib, J.G., Reynaud, C., Cedoz, J.P., et al. Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process. Br. J. Rheumatol. 36(9), 990-995 (1997).