A mitochondrial metabolite
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Acetyl-L-carnitine (chloride)

Item No. 16948

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R-(acetyloxy)-3-carboxy-N,N,N-trimethyl-1-propanaminium, monochloride
CAS Number
5080-50-2
Synonyms
  • ALCAR
  • L-Acetylcarnitine
  • C2:0 Carnitine
  • CAR 2:0
  • L-Carnitine acetyl ester
Molecular Formula
C9H18NO4 • Cl
Formula Weight
239.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/ml
λmax
209 nm
SMILES
OC(C[C@@H](OC(C)=O)C[N+](C)(C)C)=O.[Cl-]
InChi Code
InChI=1S/C9H17NO4.ClH/c1-7(11)14-8(5-9(12)13)6-10(2,3)4;/h8H,5-6H2,1-4H3;1H/t8-;/m1./s1
InChi Key
JATPLOXBFFRHDN-DDWIOCJRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    5 g

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    10 g

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    25 g

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    Product Description

    Acetyl-L-carnitine is an acetylated form of the essential mitochondrial metabolite L-carnitine (Item No. 21489) that is catabolized by plasma esterases into carnitine.1,2,3 Acetyl-L-carnitine facilitates the uptake of acetyl-CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. In vivo, acetyl-L-carnitine (100 mg/kg) increases mGlu2/3 receptor protein levels and mechanical pain thresholds in a mouse model of chronic inflammatory pain induced by complete Freund's adjuvant.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vaz, F.M., and Wanders, R.J.A. Carnitine biosynthesis in mammals. Biochem. J. 361(Pt 3), 417-429 (2002).

    2. Fu, L., Huang, M., and Chen, S. Primary carnitine deficiency and cardiomyopathy. Korean. Circ. J. 43(12), 785-792 (2013).

    3. Stieger, B., O'Neill, B., and Krähenbühl, S. Characterization of L-carnitine transport by rat kidney brush-border-membrane vesicles. Biochem. J. 309(Pt 2), 643-647 (1995).

    4. Notartomaso, S., Mascio, G., Bernabucci, M., et al. Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. Mol. Pain 13, 1744806917697009 (2017).