Sanguinarine (chloride)

Sanguinarine is a benzylisoquinoline alkaloid isolated from plants belonging to the family Papaveraceae.¹ It exhibits antimicrobial, anti-inflammatory, and anti-oxidant properties and demonstrates antiproliferative and pro-apoptotic effects in some cancer cell lines. Sanguinarine suppresses NF-κB activation by blocking the degradation of IκBα and sensitizes cancer cells to apoptosis by inducing ROS generation and activating TNF-related apoptosis-inducing ligand.² Furthermore, sanguinarine has been shown to reduce cancer cell metastasis though the inhibition of MMP-2 and MMP-9 activation and to exhibit antiangiogenic activity by downregulating VEGF-induced Akt activation.²

WARNING This product is not for human or veterinary use.

1. Ziegler, J., and Facchini, P.J. Alkaloid biosynthesis: Metabolism and trafficking. Annu. Rev. Plant Biol. 59, 735-769 (2008).

2. Gupta, S.C., Kim, J.H., Prasad, S., et al. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 29(3), 405-434 (2010).