A metabolite of sanguinarine with diverse biological activities
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Dihydrosanguinarine

Item No. 31139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
13,14-dihydro-13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine
CAS Number
3606-45-9
Synonyms
  • DHSA
Molecular Formula
C20H15NO4
Formula Weight
333.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
SMILES
CN1CC2=C(C=CC3=C2OCO3)C4=C1C(C=C(OCO5)C5=C6)=C6C=C4
InChi Code
InChI=1S/C20H15NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-7H,8-10H2,1H3
InChi Key
CIUHLXZTZWTVFL-UHFFFAOYSA-N
Origin
Plant/Macleaya cordata (Willd.) R. Br.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $43

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    5 mg

    $190

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    10 mg

    $333

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    25 mg

    $571

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    Cayman Chemical
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    Product Description

    Dihydrosanguinarine is an alkaloid and a metabolite of the alkaloid sanguinarine (Item No. 16951) that has diverse biological activities.1 It inhibits proliferation of PANC-1, SW 1990, and HPDE6c7 cancer cells when used at concentrations of 10, 20, and 30 µM.1 It also reduces the levels of phosphorylated ERK and C-RAF, halts the cell cycle at the G0/G1 and G2/M phases, and induces apoptosis in PANC-1 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, S.-Z., Xu, H.-C., Wu, X.-L., et al. Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway. Phytomedicine 59, 152895 (2019).