An active metabolite of MPTP
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MPP+ Iodide

Item No. 16958

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-4-phenyl-pyridinium, monoiodide
CAS Number
36913-39-0
Synonyms
  • N-Methyl-4-Phenylpyridinium Iodide
Molecular Formula
C12H12N • I
Formula Weight
297.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
C[N+](C=C1)=CC=C1C2=CC=CC=C2.[I-]
InChi Code
InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChi Key
RFDFRDXIIKROAI-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

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    250 mg

    $248

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    Product Description

    MPP+ is an active metabolite of MPTP, a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism.1,2,3,4 MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress.5 The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burns, R.S., Chiueh, C.C., Markey, S.P., et al. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA 80(14), 4546-4550 (1983).

    2. Fritz, R.R., Abell, C.W., Patel, N.T., et al. Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B. FEBS Lett. 186(2), 224-228 (1985).

    3. Javitch, J.A., D'Amato, R.J., Strittmatter, S.M., et al. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. USA 82(7), 2173-2177 (1985).

    4. Goshima, Y., Misu, Y., Arai, N., et al. Nanomolar L-dopa facilitates release of dopamine via presynaptic β-adrenoceptors: Comparative studies on the actions in striatal slices from control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 black mice, an animal model for Parkinson’s disease. Jpn. J. Pharmacol. 55(1), 93-100 (1991).

    5. Tieu, K. A guide to neurotoxic animal models of Parkinson’s disease. CSH Perspect. Med. 1(1), (2011).