A reversible blocker of 2-AG hydrolysis
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Monoacylglycerol Lipase Inhibitor 21

Item No. 16964

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1,1’-biphenyl]-4-hexanoic acid, 1,3-benzodioxol-5-ylmethyl ester
CAS Number
1643657-35-5
Synonyms
  • MAGL Inhibitor 21
  • MGL Inhibitor 21
Molecular Formula
C26H26O4
Formula Weight
402.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 0.5 mg/ml
λmax
250 nm
SMILES
O=C(OCC1=CC(OCO2)=C2C=C1)CCCCCC(C=C3)=CC=C3C4=CC=CC=C4
InChi Code
InChI=1S/C26H26O4/c27-26(28-18-21-13-16-24-25(17-21)30-19-29-24)10-6-1-3-7-20-11-14-23(15-12-20)22-8-4-2-5-9-22/h2,4-5,8-9,11-17H,1,3,6-7,10,18-19H2
InChi Key
WAFJKVGCIWVHQC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    MAGL inhibitor 21 selectively binds to MAGL (Ki = 0.4 µM) and reversibly blocks the enzyme’s activity in mouse brain with an IC50 value of 0.18 µM.1 Comparatively, MAGL inhibitor 21 is reported to inhibit FAAH activity in mouse brain with an IC50 value of 59 µM.2 This compound does not bind CB1 or CB2 receptors and does not inhibit the related serine hydrolases ABHD6 and ABHD12 (Kis > 10 µM).1 In a mouse model of multiple sclerosis, 5 mg/kg of MAGL inhibitor 21 has been used to ameliorate progression of the disease without producing detrimental CB1-mediated effects.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hernández-Torres, G., Cipriano, M., Hedén, E., et al. A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis. Angew. Chem. Int. Ed. Engl. 53(50), 13765-13770 (2014).

    2. Parekh, V.V., Singh, A.K., Wilson, M.T., et al. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct α- and β-anomeric glycolipids. J. Immunol. 173(6), 3693-3706 (2004).