A VEGF receptor kinase inhibitor
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ZM 306416

Item No. 16968

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine
CAS Number
690206-97-4
Synonyms
  • CB-676475
Molecular Formula
C16H13ClFN3O2
Formula Weight
333.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 20 mg/ml
λmax
219, 250, 331 nm
SMILES
COC1=C(OC)C=C(C(NC2=CC=C(Cl)C=C2F)=NC=N3)C3=C1
InChi Code
InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
InChi Key
YHUIUSRCUKUUQA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $96

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    10 mg

    $167

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    Product Description

    ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase that antagonizes the activity of KDR and Flt VEGF receptors with IC50 values of 100 nM and 2 μM, respectively.1 It has also been reported to inhibit EGFR kinase with an IC50 value of < 10 nM, reducing proliferation of EGFR-dependent cancer cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hennequin, L.F., Thomas, A.P., Johnstone, C., et al. Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J. Med. Chem. 42(26), 5369-5389 (1999).

    2. Antczak, C., Mahida, J.P., Bhinder, B., et al. A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: Implications in drug discovery. J. Biomol. Screen. 17(7), 885-899 (2012).