An anticancer flavonol
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Isomer(s)
30625Chrysosplenetin
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Casticin

Item No. 16976

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CAS Number
479-91-4
Synonyms
  • Vitexicarpin
Molecular Formula
C19H18O8
Formula Weight
374.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMF:PBS (pH 7.2) (1:5): 1 mg/mLDMSO: 10 mg/mLEthanol: 5 mg/mL
λmax
210, 258, 350 nm
SMILES
O=C1C2=C(O)C(OC)=C(OC)C=C2OC(C3=CC=C(OC)C(O)=C3)=C1OC
InChi Code
InChI=1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
InChi Key
PJQLSMYMOKWUJG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $55

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    5 mg

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    Product Description

    Casticin is a flavonol isolated from A. annua, V. trifolia, and V. agnus-castus that decreases proliferation in K562, HL-60, and Kasumi-1 leukemia cell lines (IC50s = 5.95, 4.82, and 15.56 µM, respectively).1 It blocks TGF-β/SMAD signaling in LX2 cells preventing activation, inhibiting proliferation, and inducing apoptosis of these hepatic stellate cells.2 In a mouse model of liver fibrosis, casticin (20 mg/kg) decreases TGF-β1 mRNA and phosphorylated SMAD (p-SMAD) levels. Casticin induces apoptosis in hepatocellular carcinoma (HCC) and breast cancer cells.3,4 It also downregulates Twist and prevents the epithelial-mesenchymal transition (EMT) in human HCC SMMC-7721 cells.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shen, J.-K., Du, H.-P., Yang, M., et al. Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Ann. Hematol. 88(8), 743-752 (2009).

    2. Zhou, L., Dong, X., Wang, L., et al. Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway. Oncotarget (2017).

    3. He, M., Cao, X.C., He, G.C., et al. Casticin inhibits epithelial-mesenchymal transition of liver cancer stem cells of the SMMC-7721 cell line through downregulating Twist. Oncol. Lett. 7(5), 1625-1631 (2014).

    4. Liu, L.P., Cao, X.C., Liu, F., et al. Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1. Oncol. Lett. 7(5), 1711-1717 (2014).

    5. Karim, Z.A., Zhang, J., Bangerjee, M., et al. IκB kinase phosphorylation of SNAP-23 controls platelet secretion. Blood 121(22), 4567-4574 (2013).