A flavonoid with diverse biological activities
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Isomer(s)
16976Casticin
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Chrysosplenetin

Item No. 30625

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CAS Number
603-56-5
Synonyms
  • Chrysosplenol B
  • Chrysosptertin B
  • EMD 20940
  • Polycladin
Molecular Formula
C19H18O8
Formula Weight
374.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
λmax
257, 271, 350 nm
SMILES
COC1=C(OC)C=C(OC(C2=CC=C(O)C(OC)=C2)=C(OC)C3=O)C3=C1O
InChi Code
InChI=1S/C19H18O8/c1-23-11-7-9(5-6-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
InChi Key
NBVTYGIYKCPHQN-UHFFFAOYSA-N
Origin
Plant/Laggera pterodonta
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

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    10 mg

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    Product Description

    Chrysosplenetin is a flavonoid that has been found in A. annua and has diverse biological activities.1,2,3 It is active against P. falciparum in vitro (IC50 = 23 µM).1 Chrysosplenetin inhibits the cytopathic effect of enterovirus 71 (EV71) in Vero cells (EC50 = 0.68 µM) and increases survival in a neonatal mouse model of EV71 infection when administered at doses of 1 and 5 mg/kg.2 It also increases proliferation and osteogenic differentiation of isolated human bone marrow stromal cells (BMSCs) and prevents estrogen deficiency-induced bone loss in ovariectomized mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, K.C., Yang, S.L., Roberts, M.F., et al. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. Plant Cell Rep. 11(12), 637-640 (1992).

    2. Dai, W., Bi, J., Li, F., et al. Antiviral efficacy of flavonoids against enterovirus 71 infection in vitro and in newborn mice. Viruses 11(7), 625 (2019).

    3. Hong, G., He, X., Shen, Y., et al. Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/β-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone loss. Stem Cell Res. Ther. 10(1), 277 (2019).