An inhibitor of the mitochondrial pyruvate carrier
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UK 5099

Item No. 16980

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
CAS Number
56396-35-1
Molecular Formula
C18H12N2O2
Formula Weight
288.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 5 mg/ml
λmax
210, 250, 383 nm
SMILES
O=C(/C(C#N)=C/C(C1=C2C=CC=C1)=CN2C3=CC=CC=C3)O
InChi Code
InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChi Key
BIZNHCWFGNKBBZ-JLHYYAGUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $95

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    10 mg

    $153

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    25 mg

    $294

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    Product Description

    UK 5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC) that inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 = 50 nM).1 It decreases glucose flux to the TCA cycle and increases production of M6 citrate via glutaminolytic flux through malic enzymes without affecting ATP-linked or uncoupled oxygen consumption in C2C12 myotubes when used at a concentration of 10 mM.2 UK 5099 decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES (Item No. 19284) and/or etomoxir (Item No. 11969).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Halestrap, A.P. The mitochondrial pyruvate carrier: Kinetics and specificity for substrates and inhibitors. Biochem. J. 148(1), 85-96 (1975).

    2. Vacanti, N.M., Divakaruni, A.S., Green, C.R., et al. Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol. Cell 56(3), 425-435 (2014).