An inhibitor of MDM2
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SP-141

Item No. 17003

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
CAS Number
1253491-42-7
Synonyms
  • AGN-PC-0D106I
Molecular Formula
C22H16N2O
Formula Weight
324.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 30 mg/mlEthanol: 100 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
221, 300, 365 nm
SMILES
COC1=CC2=C(C=C1)NC(C2=CC=N3)=C3C4=C(C=CC=C5)C5=CC=C4
InChi Code
InChI=1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
InChi Key
AABFWJDLCCDJJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    SP-141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM).1 Binding of MDM2 by SP-141 promotes its auto-ubiquitination and proteasomal degradation.1,2 SP-141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo.1,2 This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, W., Qin, J.J., Voruganti, S., et al. The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat. Commun. 5, 1-12 (2014).

    2. Wang, W., Qin, J.J., Voruganti, S., et al. Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. Gastroenterology 147(4), 893-902 (2014).

    3. Nag, S., Qin, J.J., Voruganti, S., et al. Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice. Biomed. Chromatogr. 29(5), 654-663 (2015).