A 5-HT1B receptor inverse agonist
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SB-224289

Item No. 17036

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)-methanone
CAS Number
180083-23-2
Molecular Formula
C32H32N4O3
Formula Weight
520.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml*
λmax
270 nm
SMILES
CN(CC1)CCC21COC3=C2C=C(N(C(C4=CC=C(C5=CC=C(C6=NOC(C)=N6)C=C5C)C=C4)=O)CC7)C7=C3
InChi Code
InChI=1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3
InChi Key
ATQMRMGXINTJHV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $63

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    10 mg

    $110

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    25 mg

    $229

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    50 mg

    $332

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    Product Description

    SB-224289 is a potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors.1 It has been used to study the role of 5-HT1B receptors in cocaine self-administration and cocaine-seeking behavior.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Selkirk, J.V., Scott, C., Ho, M., et al. SB-224289 -- A novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity. Br. J. Pharmacol. 125(1), 202-208 (1998).

    2. Pentkowski, N.S., Harder, B.G., Brunwasser, S.J., et al. Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior. ACS Chem. Neurosci. 5(3), 168-176 (2014).