An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
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CD532

Item No. 17054

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[4-[(5-cyclopentyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]amino]phenyl]-N′-[3-(trifluoromethyl)phenyl]-urea
CAS Number
1639009-81-6
Molecular Formula
C26H25F3N8O
Formula Weight
522.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
λmax
274 nm
SMILES
O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(NC3=NC(NC4=NNC(C5CCCC5)=C4)=CC=N3)C=C2
InChi Code
InChI=1S/C26H25F3N8O/c27-26(28,29)17-6-3-7-20(14-17)33-25(38)32-19-10-8-18(9-11-19)31-24-30-13-12-22(35-24)34-23-15-21(36-37-23)16-4-1-2-5-16/h3,6-16H,1-2,4-5H2,(H2,32,33,38)(H3,30,31,34,35,36,37)
InChi Key
GBMIFBVLJSCVJT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

    $213

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    25 mg

    $498

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    50 mg

    $926

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    Product Description

    CD532 is an inhibitor of Aurora A kinase activity (IC50 = 48 nM) and the protein-protein interaction between N-Myc and Aurora A kinase.1 It also inhibits several cyclin-dependent kinases (CDKs), FGFRs, MEKs, and PDGFRs, as well as FLT3, KIT, and RET at 10 µM.2 CD532 induces degradation of N-Myc in SK-N-BE(2) neuroblastoma cells (EC50 = 223 nM).1 It prevents S-phase entry in SK-N-BE(2) cells when used at a concentration of 1 µM.1 CD532 (25 mg/kg) reduces tumor growth and increases survival in a MYCN-amplified SMS-KCN neuroblastoma mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gustafson, W.C., Meyerowitz, J.G., Nekritz, E.A., et al. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell 26(3), 414-427 (2014).

    2. Lee, J.K., Phillips, J.W., Smith, B.A., et al. N-Myc drives neuroendocrine prostate cancer initiated from human prostate epithelial cells. Cancer Cell 29(4), 536-547 (2016).