A 5-HT7A and adrenergic α2 receptor antagonist
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SB-269970 (hydrochloride)

Item No. 17081

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-phenol, monohydrochloride
CAS Number
261901-57-9
Molecular Formula
C18H28N2O3S • HCl
Formula Weight
389.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
286 nm
SMILES
OC1=CC=CC(S(N2CCC[C@@H]2CCN3CCC(C)CC3)(=O)=O)=C1.Cl
InChi Code
InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
InChi Key
XQCJOYZLWFNDIO-PKLMIRHRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $203

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    25 mg

    $451

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    50 mg

    $794

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    Product Description

    SB-269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors.1 It is also reported to block adrenergic α2 receptors in guinea pig vas deferens.2 SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lovell, P.J., Bromidge, S.M., Dabbs, S., et al. A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970). J. Med. Chem. 43(3), 342-345 (2000).

    2. Foong, J.P.P., and Bornstein, J.C. 5-HT antagonists NAN-190 and SB 269970 block α2-adrenoceptors in the guinea pig. Neuroreport 20(3), 325-330 (2009).

    3. Nikiforuk, A., Kos, T., Fijal, K., et al. Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats. PLoS One 8(6), 1-12 (2013).