A copper-containing compound with diverse biological activities
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Cu-ATSM

Item No. 17122

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-4-2)-[[2,2'-(1,2-dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato-κN2,κS]](2-)]-copper
CAS Number
68341-09-3
Synonyms
  • copper-ATSM
  • CuII(atsm)
Molecular Formula
C8H14CuN6S2
Formula Weight
321.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
λmax
310, 477 nm
SMILES
CC1=[N]2[Cu]([S]C(NC)=N3)([S]C(NC)=N2)[N]3=C1C
InChi Code
InChI=1S/C8H16N6S2.Cu/c1-5(11-13-7(15)9-3)6(2)12-14-8(16)10-4;/h1-4H3,(H2,9,13,15)(H2,10,14,16);/q;+2/p-2/b11-5+,12-6+;
InChi Key
SBHDKYTVDCRMOE-JPAPVDFESA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    Cu-ATSM is a copper-containing compound with diverse biological activities.1,2,3 It inhibits ferroptotic cell death induced by RSL3, erastin (Item No. 17754), or iron(II) (EC50s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells when used at a concentration of 1 µM.1 Cu-ATSM (30 mg/kg per day) increases mutant superoxide dismutase (SOD1G37R) protein levels, metalation, and activity in the spinal cord in the SOD1G37R transgenic mouse model of amyotrophic lateral sclerosis (ALS).2 It also increases the number of α-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model. Cu-ATSM containing positron-emitting copper isotopes has been used in PET imaging applications for selective labeling of hypoxic tissue.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Southon, A., Szostak, K., Acevedo, K.M., et al. Cu II (atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease. Br. J. Pharmacol. 177(3), 656-667 (2020).

    2. Roberts, B.R., Lim, N.K.H., McAllum, E.J., et al. Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci. 34(23), 8021-8031 (2014).

    3. Vavere, A.L., and Lewis, J.S. Cu-ATSM: A radiopharmaceutical for the PET imaging of hypoxia. Dalton Trans. 43, 4893-4902 (2007).