A selective adenosine A2B receptor agonist
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BAY 60-6583

Item No. 17127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide
CAS Number
910487-58-0
Molecular Formula
C19H17N5O2S
Formula Weight
379.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 0.3 mg/ml
λmax
253, 288, 344 nm
SMILES
O=C(CSC1=NC(N)=C(C(C2=CC=C(C=C2)OCC3CC3)=C1C#N)C#N)N
InChi Code
InChI=1S/C19H17N5O2S/c20-7-14-17(12-3-5-13(6-4-12)26-9-11-1-2-11)15(8-21)19(24-18(14)23)27-10-16(22)25/h3-6,11H,1-2,9-10H2,(H2,22,25)(H2,23,24)
InChi Key
ZTYHZMAZUWOXNC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $169

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    25 mg

    $378

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    Cayman Chemical
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    Product Description

    BAY 60-6583 is an adenosine A2B receptor agonist (EC50 = 3 nM for human A2B receptors) that displays selectivity over A1, A2A, and A3 receptors (EC50s = >10 µM).1 It has been used to decrease superoxide production in neutrophils and to study the role of the A2B receptor in regulating inflammation and mediating metabolic homeostasis in a mouse model of type 2 diabetes and obesity.2,3 BAY 60-6583 has also been examined for potential clinical use in disorders of the coronary arteries and atherosclerosis and in ischemia-reperfusion injury.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baraldi, P.G., Tabrizi, M.A., Fruttarolo, F., et al. Recent improvements in the development of A2B adenosine receptor agonists. Purinergic Signal. 5(1), 3-19 (2009).

    2. van der Hoeven, D., Wan, T.C., Gizewski, E.T., et al. A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. J. Pharmacol. Exp. Ther. 338(3), 1004-1012 (2011).

    3. Johnston-Cox, H., Koupenova, M., Yang, D., et al. The A2b adenosine receptor modulates glucose homeostasis and obesity. PLoS One 7(7), 1-9 (2012).