A thrombin inhibitor
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Dabigatran

Item No. 17133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine
CAS Number
211914-51-1
Synonyms
  • BIBR 953
Molecular Formula
C25H25N7O3
Formula Weight
471.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.5 mg/ml (@*25°C )
λmax
224, 315 nm
SMILES
CN1C2=CC=C(C(N(CCC(O)=O)C3=NC=CC=C3)=O)C=C2N=C1CNC4=CC=C(C(N)=N)C=C4
InChi Code
InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)
InChi Key
YBSJFWOBGCMAKL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    50 mg

    $667

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    Product Description

    Dabigatran is an inhibitor of thrombin (Ki = 0.0045 µM) and an active metabolite of the thrombin inhibitor prodrug dabigatran etexilate (Item No. 17131).1,2 It also inhibits trypsin (Ki = 0.0503 µM) but is selective for thrombin and trypsin over plasmin, Factor Xa, activated protein C, and tissue plasminogen activator (tPA; Kis = 1.695, 3.76, 20.93, and 45.36 µM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hauel, N.H., Nar, H., Priepke, H., et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J. Med. Chem. 45(9), 1757-1766 (2002).

    2. Eisert, W.G., Hauel, N., Stangier, J., et al. Dabigatran: An oral novel potent reversible nonpeptide inhibitor of thrombin. Arterioscler. Thromb. Vasc. Biol. 30(10), 1885-1889 (2010).