An active metabolite of dabigatran
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Dabigatran Acyl-β-D-Glucuronide (trifluoroacetate salt)

Item No. 39046

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine, β-D-glucopyranuronosyl ester, trifluoroacetate salt
Synonyms
  • Dabigatran β-1-O-Acyl Glucuronide
Molecular Formula
C31H33N7O9 • XCF3COOH
Formula Weight
647.6
Purity
≥75%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
CN1C2=CC=C(C(N(CCC(O[C@@H]3O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=O)C4=NC=CC=C4)=O)C=C2N=C1CNC5=CC=C(C(N)=N)C=C5.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C31H33N7O9.C2HF3O2/c1-37-20-10-7-17(14-19(20)36-22(37)15-35-18-8-5-16(6-9-18)28(32)33)29(43)38(21-4-2-3-12-34-21)13-11-23(39)46-31-26(42)24(40)25(41)27(47-31)30(44)45;3-2(4,5)1(6)7/h2-10,12,14,24-27,31,35,40-42H,11,13,15H2,1H3,(H3,32,33)(H,44,45);(H,6,7)/t24-,25-,26+,27-,31+;/m0./s1
InChi Key
RRCUNSDOLKLUGK-OIADZRQFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $886

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    Product Description

    Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor dabigatran (Item No. 17133).1,2 It is formed from dabigatran primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15. Dabigatran acyl-β-D-glucuronide (0.46 µM) increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eisert, W.G., Hauel, N., Stangier, J., et al. Dabigatran: An oral novel potent reversible nonpeptide inhibitor of thrombin. Arterioscler. Thromb. Vasc. Biol. 30(10), 1885-1889 (2010).

    2. Ebner, T., Wagner, K., and Wienen, W. Dabigatran acylglucuronide, the major human metabolite of dabigatran: In vitro formation, stability, and pharmacological activity. Drug. Metab. Dispos. 38(9), 1567-1575 (2010).