A 2-deoxyglucose derivative
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Carbohydrate Metabolism

2-deoxy-D-Glucose-6-phosphate (sodium salt)

Item No. 17149

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(dihydrogen phosphate) 2-deoxy-D-arabino-hexose, monosodium salt
Synonyms
  • 2-Deoxyglucose-6-phosphate
  • 2-DG6P
Molecular Formula
C6H12O8P • Na
Formula Weight
266.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=CC[C@@H](O)[C@H](O)[C@H](O)COP(O)([O-])=O.[Na+]
InChi Code
InChI=1S/C6H13O8P.Na/c7-2-1-4(8)6(10)5(9)3-14-15(11,12)13;/h2,4-6,8-10H,1,3H2,(H2,11,12,13);/q;+1/p-1/t4-,5-,6+;/m1./s1
InChi Key
UYBJQNKBTZPKLV-JMWSHJPJSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $55

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    25 mg

    $108

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    50 mg

    $149

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    100 mg

    $274

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    Product Description

    2-deoxy-D-Glucose (2-DG, Item No. 14325) is a synthetic analog of glucose used in cell metabolism and cancer research.1 2-deoxy-D-Glucose-6-phosphate (2-DG6P) is a derivative of 2-DG. It is produced in mammalian cells by the action of hexokinase on 2-DG. The accumulation of 2-DG6P in cells can inhibit glycolysis, leading to cell death.2 However, the uptake of 2-DG by cells can be monitored in assays by the accumulation of 2-DG6P, which can be oxidized in vitro by glucose 6-phosphate dehydrogenase and reduce NADP+. In bacteria and yeast, 2-DG6P is metabolized to 2-DG by 2-DG6P phosphatase.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, H.T., and Hwang, E.S. 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78(12), 1392-1399 (2006).

    2. Urakami, K., Zangiacomi, V., Yamaguchi, K., et al. Impact of 2-deoxy-D-glucose on the target metabolite profile of a human endometrial cancer cell line. Biomed. Res. 34(5), 221-229 (2013).

    Product Citations

    Singh, S.R., Zeng, X., Zhao, J., et al. The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila. Nature 538(7623), 109-113 (2016).