A glucose antimetabolite and an inhibitor of glycolysis
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2-deoxy-D-Glucose

Item No. 14325

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-deoxy-D-arabino-hexose
CAS Number
154-17-6
Synonyms
  • Ba 2758
  • 2-DG
  • NSC 15193
Molecular Formula
C6H12O5
Formula Weight
164.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O[C@@H]1[C@@H](CO)OC(O)C[C@H]1O
InChi Code
InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1
InChi Key
PMMURAAUARKVCB-CERMHHMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $58

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    5 g

    $229

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    10 g

    $429

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    25 g

    $1,001

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    Product Description

    2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2 It is metabolized by hexokinase into 2-deoxy-D-glucose-6-phosphate (2-DG6P), which cannot be metabolized by glucose-6-phosphate isomerase, leading to 2-DG6P accumulation, inhibition of glycolysis, and cell death.3 2-deoxy-D-glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.4,5 In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Item No. 15007) or paclitaxel (Item No. 10461).6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, H.T., and Hwang, E.S. 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78(12), 1392-1399 (2006).

    2. Aft, R.L., Zhang, F.W., and Gius, D. Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death. Br. J. Cancer 87(7), 805-812 (2002).

    3. Pajak, B., Siwiak, E., Sołtyka, M., et al. 2-deoxy-d-glucose and its analogs: From diagnostic to therapeutic agents. Int. J. Mol. Sci. 21(1), 234 (2019).

    4. Liu, H., Savaraj, N., Priebe, W., et al. Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: A strategy for solid tumor therapy (Model C). Biochem. Pharmacol. 64(12), 1745-1751 (2002).

    5. Zhang, X.D., Deslandes, E., Villedieu, M., et al. Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro. Anticancer Res. 26(5A), 3561-3566 (2006).

    6. Maschek, G., Savaraj, N., Priebe, W., et al. 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res. 64(1), 31-34 (2004).

    Product Citations

    Kremer, D.M., Nelson, B.S., Lin, L., et al. GOT1 inhibition primes pancreatic cancer for ferroptosis through the autophagic release of labile iron. bioRxiv (2020).

    Bessho, R., Davidoff, O., Kobayashi, H., et al. Regional metabolic analysis of structurally preserved kidney slices by ex vivo respirometry. Am. J. Physiol. Renal Physiol. 329(6), F796-F808 (2025).