An insecticidal antibiotic
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Milbemycin oxime

Item No. 17164

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
oxime milbemycin
CAS Number
129496-10-2
Molecular Formula
2C31H43NO7 (A3:80%) and 2C32H45NO7 (A4:20%)
Formula Weight
2194.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
246 nm
SMILES
C[C@H]([C@@H](C)CC1)O[C@]21C[C@](OC([C@@]3([H])[C@@]4(O)[C@@]5([H])/C(C(C)=C3)=N\O)=O)([H])C[C@](C/C=C(C)/C[C@@H](C)/C=C/C=C4\CO5)([H])O2.CC[C@H]([C@@H](C)CC6)O[C@]76C[C@](OC([C@@]8([H])[C@@]9(O)[C@@]%10([H])/C(C(C)=C8)=N\O)=O)([H])C[C@](C/C=C(C)/C[C@@H](C)/C=C/C=C9\CO%10)([H])O7.C[C@H]([C@@H](C)CC%11)O[C@]%12%11C[C@](OC([C@@]%13([H])[C@@]%14(O)[C@@]%15([H])/C(C(C)=C%13)=N\O)=O)([H])C[C@](C/C=C(C)/C[C@@H](C)/C=C/C=C%14\CO%15)([H])O%12.CC[C@H]([C@@H](C)CC%16)O[C@]%17%16C[C@](OC([C@@]%18([H])[C@@]%19(O)[C@@]%20([H])/C(C(C)=C%18)=N\O)=O)([H])C[C@](C/C=C(C)/C[C@@H](C)/C=C/C=C%19\CO%20)([H])O%17
InChi Code
InChI=1S/2C32H45NO7.2C31H43NO7/c2*1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35;2*1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h2*7-10,15,19,21,24-27,29,35-36H,6,11-14,16-18H2,1-5H3;2*6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3/b2*8-7+,20-10+,23-9+,33-28-;2*7-6+,19-9+,23-8+,32-27-/t2*19-,21-,24+,25-,26-,27+,29+,31+,32+;2*18-,20-,22+,24+,25-,26-,28+,30-,31+/m0000/s1
InChi Key
LKMMLHTWKLEARD-OAXGTHRDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Milbemycin oxime is a semisynthetic macrocyclic lactone prepared by the oxidation and oximation of an 80:20 ratio of milbemycin A3 and A4 (Item No. 17155). Like other milbemycin/avermectins, it can potentiate glutamate and GABA-gated chloride-channel opening and is used as a nematocide and insecticide in veterinary medicine.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Duke, S.O., Cantrell, C.L., Meepagala, K.M., et al. Natural toxins for use in pest management. Toxins (Basel) 2(8), 1943-1962 (2010).

    2. Bienhoff, S.E., Kok, D.J., Roycroft, L.M., et al. Efficacy of a single oral administration of milbemycin oxime against natural infections of Ancylostoma braziliense in dogs. Vet. Parasitol. 195(1-2), 102-105 (2013).