A selective dopamine D4 receptor antagonist
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Product Categories

Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Neuroscience

Application

RBI 257 (maleate)

Item No. 17223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[1-[(4-iodophenyl)methyl]-4-piperidinyl]-N-methyl-3-(1-methylethoxy)-2-pyridinamine (2Z)-2-butenedioate
CAS Number
911378-38-6
Molecular Formula
C21H28IN3O • C4H4O4
Formula Weight
581.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
240, 295 nm
SMILES
IC1=CC=C(CN2CCC(N(C)C3=NC=CC=C3OC(C)C)CC2)C=C1.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C21H28IN3O.C4H4O4/c1-16(2)26-20-5-4-12-23-21(20)24(3)19-10-13-25(14-11-19)15-17-6-8-18(22)9-7-17;5-3(6)1-2-4(7)8/h4-9,12,16,19H,10-11,13-15H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
NIRRRTUKUHIOTQ-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $333

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    10 mg

    $553

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    Product Description

    RBI 257 is a potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kula, N.S., Baldessarini, R.J., Kebabian, J.W., et al. RBI-257: A highly potent dopamine D4 receptor-selective ligand. Eur. J. Pharmacol. 331, 333-336 (1997).