A potent, selective EGFR inhibitor
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BPIQ-II (hydrochloride)

Item No. 17226

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-bromophenyl)-3H-imidazo[4,5-g]quinazolin-8-amine, monohydrochloride
CAS Number
171179-37-6
Synonyms
  • PD 158294
Molecular Formula
C15H10BrN5 • HCl
Formula Weight
376.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
λmax
232, 349 nm
SMILES
BrC1=CC(NC2=NC=NC3=C2C=C(NC=N4)C4=C3)=CC=C1.Cl
InChi Code
InChI=1S/C15H10BrN5.ClH/c16-9-2-1-3-10(4-9)21-15-11-5-13-14(19-7-18-13)6-12(11)17-8-20-15;/h1-8H,(H,18,19)(H,17,20,21);1H
InChi Key
FENLVGDZGJBHPT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $101

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    1 mg

    $181

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    5 mg

    $700

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    Product Description

    BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM).1 It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rewcastle, G.W., Palmer, B.D., Bridges, A.J., et al. Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor. J. Med. Chem. 39(4), 918-928 (1996).