A P2X1 receptor antagonist
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NF 023 (hydrate)

Item No. 17234

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,8′-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt
CAS Number
1219024-70-0
Molecular Formula
C35H20N4O21S6 • 6Na • XH2O
Formula Weight
1030.9
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 100 mM
SMILES
O=C(NC1=CC=CC(C(NC2=CC=C(S(=O)([O-])=O)C3=CC(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C23)=O)=C1)NC4=CC=CC(C(NC5=CC=C(S(=O)([O-])=O)C6=CC(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C56)=O)=C4.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C35H26N4O21S6.6Na/c40-33(38-25-7-9-27(63(49,50)51)23-13-21(61(43,44)45)15-29(31(23)25)65(55,56)57)17-3-1-5-19(11-17)36-35(42)37-20-6-2-4-18(12-20)34(41)39-26-8-10-28(64(52,53)54)24-14-22(62(46,47)48)16-30(32(24)26)66(58,59)60;;;;;;/h1-16H,(H,38,40)(H,39,41)(H2,36,37,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60);;;;;;/q;6*+1/p-6
InChi Key
FMQURVHYTBGYSQ-UHFFFAOYSA-H
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    NF 023 is a purinergic P2X1 receptor antagonist (IC50 = 0.21 µM).1 It is selective for P2X1 over P2X2-4 receptors (IC50s = >50, 28.9 and >100 µM, respectively). It inhibits α,β-methylene ATP-induced vasoconstriction in isolated rabbit saphenous arteries (pA2 = 5.69).2 NF 023 also inhibits hepatitis C virus (HCV) NS3 helicase (IC50 = 6.2 µM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Soto, F., Lambrecht, G., Nickel, P., et al. Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 38(1), 141-149 (1999).

    2. Ziyal, R., Ziganshin, A.U., Nickel, P., et al. Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery. Br. J. Pharmacol. 120(5), 954-960 (1997).

    3. Mukherjee, S., Hanson, A.M., Shadrick, W.R., et al. Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays. Nucleic Acids Res. 40(17), 8607-8621 (2021).