A potent EGFR inhibitor
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Compound 56

Item No. 17254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-bromophenyl)-6,7-diethoxy-4-quinazolinamine
CAS Number
171745-13-4
Molecular Formula
C18H18BrN3O2
Formula Weight
388.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.25 mg/mlEthanol: 2 mg/ml
λmax
208, 230, 252, 333 nm
SMILES
BrC1=CC(NC2=NC=NC3=C2C=C(OCC)C(OCC)=C3)=CC=C1
InChi Code
InChI=1S/C18H18BrN3O2/c1-3-23-16-9-14-15(10-17(16)24-4-2)20-11-21-18(14)22-13-7-5-6-12(19)8-13/h5-11H,3-4H2,1-2H3,(H,20,21,22)
InChi Key
YXOXHAUUTIOBDA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $262

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    1 mg

    $498

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    Product Description

    Compound 56 is a highly potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 0.006 nM).1 It has been used to inhibit EGFR activity in pancreatic cancer cell lines and to induce the differentiation of rat mesenchymal stem cells.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bridges, A.J., Zhou, H., Cody, D.R., et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J. Med. Chem. 39(1), 267-276 (1996).

    2. Chandana, S.R., Leece, C.M., Gallo, K.A., et al. Inhibition of MLK3 decreases proliferation and increases antiproliferative activity of epidermal growth factor receptor (EGFR) inhibitor in pancreatic cancer cell lines. Cancer Growth Metastasis 3, 1-9 (2010).

    3. Hwang, K.C., Kim, J.Y., Chang, W., et al. Chemicals that modulate stem cell differentiation. Proc. Natl. Acad. Sci. USA 105(21), 7467-7471 (2008).