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WAY-161503

Item № 17269
CAS № 75704-24-4
Purity ≥98%
product image
                (CAS 75704-24-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $25.00 0.00
     5 mg $75.00 0.00
     10 mg $125.00 0.00
     50 mg $500.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description

WAY-161503 is a full agonist of 5-HT2C receptors (Ki = 3.3 nM for displacement of DOI (Item No. 13885)).1 Relative to 5-HT2C receptor binding, WAY-161503 is ~6-fold less potent at 5-HT2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT2B receptors (Ki = 60 nM).1 In functional studies, WAY-161503 can stimulate calcium mobilization coupled to 5-HT2C, 2B, and 2A receptors with EC50 values of 0.8, 1.8, and 7 nM, respectively.1 WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED50 values of 1.9, 6.8, and 0.73 mg/kg, respectively.1 This compound has been used to examine the role of 5-HT2C receptors in rodent models of depression, locomotion, reinforcement, or motivated behaviors.2,3

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Technical Information
Formal Name
8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one
CAS Number
75704-24-4
Molecular Formula
C11H11Cl2N3O
Formula Weight
272.1
Purity
≥98%
Formulation
A crystalline solid
λmax
230 nm
SMILES
O=C1NC2=CC(Cl)=C(Cl)C=C2N3C1CNCC3
InChI Code
InChI=1S/C11H11Cl2N3O/c12-6-3-8-9(4-7(6)13)16-2-1-14-5-10(16)11(17)15-8/h3-4,10,14H,1-2,5H2,(H,15,17)
InChI Key
PHGWDAICBXUJDU-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Rosenzweig-Lipson, S., Zhang, J., Mazandarani, H., et al. Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503 Brain Research 1073-1074, 240-251 (2006).

2. Cryan, J.F., and Lucki, I. Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors Journal of Pharmacology and Experimental Therapeutics 295(3), 1120-1126 (2000).

3. Hayes, D.J., Mosher, T.M., and Greenshaw, A.J. Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats Behavioural Brain Research 197(2), 323-330 (2009).

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